Podcasts have changed my life. I've really gotten into them over the last year and a half or so. Really helps with my commute and it's nice to listen to something other than music every once in a while.

Stuff I love:
The Andy Daly Podcast Pilot Project
Before You Were Funny
Call Chelsea Peretti
Comedy Bang Bang
How Did This Get Made?
James Bonding
The Indoor Kids
The Nerdist
Nocturnal Emotions
Professor Blastoff
Steve Agee: Uhhh
This Feels Terrible

The latest thing I'm loving is U Talkin' U2 To Me with Scott Aukerman and Adam Scott. It's a U2 podcast, but they hardly talk about U2 and mostly just do bits. It's great. Will have to check out some of the other podcasts mentioned in this thread.